An animation of human cell membrane receptor ACE2 (golden) being recognised by SARS-CoV-2 Spike Glycoprotein (red).
The Receptor Binding Domain (RBD) of the Spike protein transitions from a retracted state to an erect state in order to determine the suitability of a potential target cell for infection.
Mutations that destabilise the retracted conformation of the RBD may render new viral strains more infectious.
Cryo-Electron Microscopy map EMD-11684.
Human ACE2 1R42.
SARS-CoV-2 Spike Glycoprotein 6XLU.
Several components of the Situs package (collage, colores, ddforge, pdb2vol, map2map).