{"id":295,"date":"2021-01-11T15:33:53","date_gmt":"2021-01-11T15:33:53","guid":{"rendered":"https:\/\/sciting.eu\/sciting\/?page_id=295"},"modified":"2021-01-11T19:31:44","modified_gmt":"2021-01-11T19:31:44","slug":"covid-19-structural-biology","status":"publish","type":"page","link":"https:\/\/sciting.eu\/sciting\/samples\/pedagogical-resources\/covid-19-structural-biology\/","title":{"rendered":"COVID-19 Structural Biology"},"content":{"rendered":"\n<p>An animation of human cell membrane receptor ACE2 (golden) being recognised by SARS-CoV-2 Spike Glycoprotein (red). <\/p>\n\n\n\n<p>The Receptor Binding Domain (RBD) of the Spike protein transitions from a retracted state to an erect state in order to determine the suitability of a potential target cell for infection.<\/p>\n\n\n\n<p>Mutations that destabilise the retracted conformation of the RBD may render new viral strains more infectious. <\/p>\n\n\n\n<figure class=\"wp-block-embed is-type-video is-provider-youtube wp-block-embed-youtube wp-embed-aspect-16-9 wp-has-aspect-ratio\"><div class=\"wp-block-embed__wrapper\">\n<iframe loading=\"lazy\" title=\"Recognition of human ACE2 by SARS-CoV-2 Spike protein\" width=\"500\" height=\"281\" src=\"https:\/\/www.youtube.com\/embed\/nTIw-FA6IkU?feature=oembed\" frameborder=\"0\" allow=\"accelerometer; autoplay; clipboard-write; encrypted-media; gyroscope; picture-in-picture; web-share\" referrerpolicy=\"strict-origin-when-cross-origin\" allowfullscreen><\/iframe>\n<\/div><\/figure>\n\n\n\n<p><\/p>\n\n\n\n<p>CAST<\/p>\n\n\n\n<p>Cryo-Electron Microscopy map <a href=\"https:\/\/www.nature.com\/articles\/s41586-020-2772-0\" target=\"_blank\" rel=\"noreferrer noopener\">EMD-11684<\/a>.<\/p>\n\n\n\n<p>Human ACE2 <a href=\"https:\/\/www.jbc.org\/content\/279\/17\/17996\" target=\"_blank\" rel=\"noreferrer noopener\">1R42.<\/a><\/p>\n\n\n\n<p>SARS-CoV-2 Spike Glycoprotein <a href=\"https:\/\/www.biorxiv.org\/content\/10.1101\/2020.07.04.187989v2\" target=\"_blank\" rel=\"noreferrer noopener\">6XLU<\/a>.<\/p>\n\n\n\n<p>SOFTWARE<\/p>\n\n\n\n<p>Several components of the <a rel=\"noreferrer noopener\" href=\"http:\/\/situs.biomachina.org\/\" target=\"_blank\">Situs<\/a> package (collage, colores, ddforge, pdb2vol, map2map).<\/p>\n\n\n\n<p><a rel=\"noreferrer noopener\" href=\"https:\/\/github.com\/openmm\/pdbfixer\" target=\"_blank\">PDBFixer<\/a>, <a rel=\"noreferrer noopener\" href=\"https:\/\/salilab.org\/modeller\/\" target=\"_blank\">MODELLER<\/a>, <a rel=\"noreferrer noopener\" href=\"https:\/\/www.cgl.ucsf.edu\/chimera\/\" target=\"_blank\">UCSF Chimera<\/a>, Manjaro Linux.<\/p>\n\n\n\n<div class=\"wp-block-image is-style-default\"><figure class=\"aligncenter size-large\"><a href=\"https:\/\/sciting.eu\/sciting\/\"><img decoding=\"async\" src=\"https:\/\/sciting.eu\/sciting\/wp-content\/uploads\/2021\/01\/sciting_logo_medium-1.png\" alt=\"\"\/><\/a><\/figure><\/div>\n","protected":false},"excerpt":{"rendered":"<p>An animation of human cell membrane receptor ACE2 (golden) being recognised by SARS-CoV-2 Spike Glycoprotein (red). The Receptor Binding Domain (RBD) of the Spike protein transitions from a retracted state to an erect state in order to determine the suitability of a potential target cell for infection. Mutations that destabilise the retracted conformation of the [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"parent":246,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"footnotes":""},"class_list":["post-295","page","type-page","status-publish","hentry"],"_links":{"self":[{"href":"https:\/\/sciting.eu\/sciting\/wp-json\/wp\/v2\/pages\/295","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/sciting.eu\/sciting\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/sciting.eu\/sciting\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/sciting.eu\/sciting\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/sciting.eu\/sciting\/wp-json\/wp\/v2\/comments?post=295"}],"version-history":[{"count":4,"href":"https:\/\/sciting.eu\/sciting\/wp-json\/wp\/v2\/pages\/295\/revisions"}],"predecessor-version":[{"id":304,"href":"https:\/\/sciting.eu\/sciting\/wp-json\/wp\/v2\/pages\/295\/revisions\/304"}],"up":[{"embeddable":true,"href":"https:\/\/sciting.eu\/sciting\/wp-json\/wp\/v2\/pages\/246"}],"wp:attachment":[{"href":"https:\/\/sciting.eu\/sciting\/wp-json\/wp\/v2\/media?parent=295"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}